Adelaide researchers are challenging decades-old assumptions about brain cancer treatment in a bid to make radiation therapy more effective against tumours, while reducing damage to healthy tissue.
The U.S. National Science Foundation is investing $90 million over five years to support three new NSF Science and Technology Centers (NSF STC). These centers will advance American leadership in…
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Precise manipulation of large genomic fragments is a critical need in crop breeding and synthetic biology. In crop genomes, superior traits are often associated with structural variations. However, existing large-fragment editing tools such as CRISPR-Cas systems and site-specific recombinases have limitations. In 2024, the development of the bridge RNA-guided IS110-family recombinase system provid
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DNA double-strand breaks (DSBs) are posing serious threats to genome stability. During mitosis, cells mainly rely on polymerase theta (Polθ) -mediated repair to fix these breaks. However, how the CIP2A-TOPBP1 complex regulates this process remains unclear. In a study published in PNAS , a team led by Prof. ZHAO Guoping from the Hefei Institutes of Physical Science of the Chinese Academy of Science
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LBMS marks five years as a leading cryo-EM facility, advancing biological discovery through cutting-edge imaging and collaboration.
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Researchers uncover a critical molecular switch that helps bacteria survive environmental stress and antibiotic exposure.
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Research NewsUniversity of Minnesota Medical School
Early Investment in an Emerging Scientist The Children’s Cancer Research Fund (CCRF) recently visited the Center for Genome Engineering at the University of Minnesota.
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In collaboration with Professor Shinse Yamaga and Professor Chisa Shukuminami of the Department of Biomolecular Functions, Graduate School of Medical Sciences, Hiroshima University, and Professor Kenta Sumiyama of the Graduate School of Bioagricultural Sciences, Nagoya University, Assistant Professor Hitomi Watanabe, Professor Gen Kondo of the Institute of Medical Biology, Kyoto University, and others, they identified an enhancer (*2) that controls the expression of the transcription factor Scx (*1), which is essential for the maturation of tendons and ligaments, and clarified its role. Our research group first analyzed the activity of candidate genomic regions using lacZ Tg mouse (*3) embryos and revealed that a 5.3kb genomic region that includes part of the mouse Scx gene and its downstream region has enhancer activity. Furthermore, we found that the evolutionarily highly conserved region (CSE) contained in this 5.3kb region also has enhancer activity. Next, when we created and analyzed mice lacking CSE using genome editing technology, we found that Scx expression was significantly reduced during the limb formation process. Also, usually
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Soil salinization poses a serious threat to global rice production. At present, the natural‑variation‑based genetic basis of rice salt tolerance remains poorly understood, and only a handful of major genes related to salt tolerance have been functionally characterized. It is critical to identify key gene modules in salt signaling pathways. In a study published in Developmental Cell on August 28, a
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Upgraded facilities designed to promote research innovation, collaboration
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The long-term future of the South Australian Health and Medical Research Institute has been secured with a landmark agreement that will bolster South Australia's global health and medical research capabilities.
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A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
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Dr. Sam Ward is currently transitioning away from his role as vice dean for research in the School of Medicine and is a professor in the Departments of Orthopaedic Surgery and Radiology in the School of Medicine and Bioengineering in the Jacobs School of Engineering.
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Research NewsUniversity of Minnesota Medical School
Celebrating two decades of impact, the University of Minnesota’s Program in Health Disparities Research (PHDR) transformed community-engaged research from an overlooked initiative into a mainstream academic standard, redefining institutional excellence, trust, and research funding along the way.
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by Marc Chalufour August 27, 2026 Illustrations by Adrià Fruitós Infectious Disease , Cancer , Public Health , School of Medicine Share When Karl Munger was a postdoctoral researcher at the National Institutes of Health in the late 1980s, he landed in the lab of pioneering virologist Peter Howley and began studying human papillomavirus. Scientists had noticed that HPV was often present in cervical cancer. But was it merely present, or did it drive the growth of cancer? Munger was able to show th
Using a new combination of computational tools to analyze ancient DNA , Yale researchers have discovered two ancient, extinct giant tortoise lineages that once lived on the Galapagos Islands.
The center was established in 2021 as a developmental center in partnership with UTHealth Houston, Baylor College of Medicine, and the Texas Biomedical Research Institute.
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