DNA double-strand breaks (DSBs) are posing serious threats to genome stability. During mitosis, cells mainly rely on polymerase theta (Polθ) -mediated repair to fix these breaks. However, how the CIP2A-TOPBP1 complex regulates this process remains unclear. In a study published in PNAS , a team led by Prof. ZHAO Guoping from the Hefei Institutes of Physical Science of the Chinese Academy of Science
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In a study published in Science , a team led by Prof. ZHOU Bin from the Center for Excellence in Molecular Cell Science (Shanghai Institute of Biochemistry and Cell Biology) of the Chinese Academy of Sciences, along with Prof. LIU Kathy O. from The Chinese University of Hong Kong, developed a series of genetic lineage-tracing tools to investigate the origins of newly formed coronary collateral art
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In a study published in Cell , a team led by Prof. ZHOU Bin from the Center for Excellence in Molecular Cell Science (Shanghai Institute of Biochemistry and Cell Biology) of the Chinese Academy of Sciences, along with Prof. Ralf H. Adams from the Max Planck Institute for Molecular Biomedicine, Germany, reported the absence of lymphatic vessels in homeostasis and regenerating bone and their abnorma
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Adelaide researchers are challenging decades-old assumptions about brain cancer treatment in a bid to make radiation therapy more effective against tumours, while reducing damage to healthy tissue.
The U.S. National Science Foundation is investing $90 million over five years to support three new NSF Science and Technology Centers (NSF STC). These centers will advance American leadership in…
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Stem cells possess the unique ability to self-renew and transform into different types of cells. For example, rare hematopoietic stem cells found in bone marrow can become any type of blood cell. Throughout life, they can produce new blood cells to replace those lost because of infection, bleeding, or chemotherapy. However, as people and animals age, hematopoietic stem cells become less effective.
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When Raghav Sehgal arrived at Yale as a graduate student several years ago, he wanted to explore the use of powerful computer science tools in cancer research. With an engineering background and a computational biology startup already under his belt, he was well prepared.
The first wave of blockbuster obesity medications, including semaglutide (Ozempic, Wegovy) and tirzepatide (Zepbound, Mounjaro), transformed weight loss by achieving levels once thought possible only with bariatric surgery.
Australian researchers have uncovered a promising new way to tackle one of the most aggressive forms of breast cancer, raising hopes for more effective treatments to stop the disease from spreading.
LBMS marks five years as a leading cryo-EM facility, advancing biological discovery through cutting-edge imaging and collaboration.
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Researchers uncover a critical molecular switch that helps bacteria survive environmental stress and antibiotic exposure.
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Research NewsUniversity of Minnesota Medical School
Early Investment in an Emerging Scientist The Children’s Cancer Research Fund (CCRF) recently visited the Center for Genome Engineering at the University of Minnesota.
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Research NewsLawrence Berkeley National Laboratory
Scientists around the world use the focused beams of light generated by the Advanced Light Source (ALS) synchrotron to study molecules and materials with…
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Glycosphingolipids (GSLs) are sugar-containing membrane lipids that help organize cell surfaces and regulate signaling, immune recognition, differentiation and neuronal function. Human cells produce several hundred GSL species through stepwise modification of their sugar groups, and this diversity begins with a single committed reaction, in which uridine diphosphate glucose (UDP-glucose) ceramide
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Have you ever wondered how a flower ensures that it's pollen-catching "landing pad" (the stigma) stays neatly separated from the "pollen tube highway" beneath it (the style)? This clear boundary is crucial for plant reproduction, but for decades, biologists didn't know how it was drawn. In a study published in PNAS , researcher s from the Institute of Botany of the Chinese Academy of Sciences (CAS
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Scientists have recently reconstructed the ancestral karyotype of the banana family, revealing how chromosome numbers decreased stepwise from 17 to 9 - 11 over evolutionary time. The study was led by scientists from the South China Botanical Garden (SCBG) of the Chinese Academy of Sciences (CAS), in collaboration with researchers from Sichuan University and other institutions . The findings were p
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Scientists have recently revealed the molecular mechanism of the MsWRKY65– MsLNC1 –MsTRX5 module conferring resistance to Valsa canker in wild apple. Led by Prof. Z HANG Daoyuan from the Xinjiang Institute of Ecology and Geography (XIEG) of the Chinese Academy of Sciences (CAS), the study was published in Horticulture Research . Apple Valsa canker, caused by the necrotrophic fungus Valsa mali , le
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In a study published in BMC Biology , researchers from the Xishuangbanna Tropical Botanical Garden (XTBG) of the Chinese Academy of Sciences and Lanzhou University revealed a sophisticated natural selection process that protects closely related spruce trees from the genetic chaos of interbreeding. These findings provide new evidence for taxonomic delimitation , helping scientists distinguish speci
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