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Research News

Mayo Clinic study estimates cancer risk in patients with pancreatic cysts, advancing early detection

ROCHESTER, Minn. — Mayo Clinic researchers have estimated the risk that pancreatic cysts with worrisome or high-risk features will progress to pancreatic cancer or advanced precancerous changes within three years. The findings, published in Gastroenterology, could help physicians and patients better assess risk and make more informed decisions about whether to monitor a cyst or […]

Research News

Mayo Clinic AI model helps clinicians detect heart obstruction using routine ultrasound images

PHOENIX — Mayo Clinic researchers have developed and externally validated an artificial intelligence (AI) model that can identify a potentially significant heart obstruction from routine ultrasound videos without relying on specialized Doppler imaging. The technology could help clinicians flag patients with hypertrophic cardiomyopathy (HCM) who may need additional testing, particularly in settings where specialized echocardiography […]

Research News

International study identifies promising therapy to prevent relapses in rare neurological disease

ROCHESTER, Minn. — An international study led by Mayo Clinic researchers has identified interleukin-6 (IL-6) receptor blockers as a promising option for preventing relapses in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). MOGAD is a rare autoimmune neurological disorder that can cause vision loss, paralysis and other serious neurological complications. The study, published in JAMA Neurology, […]

Research News

How scientists hope to retrain the immune system after an organ transplant

Organ transplantation has transformed countless lives, offering hope to people with end-stage organ failure. But for many patients, the journey doesn't end with surgery. Lifelong anti-rejection medications protect transplanted organs, but they also can increase the risk of infection, cancer and other serious health complications. On the latest episode of "Tomorrow's Cure," host Lindsay Sievert […]

Research News

First-in-class small molecule inhibitor designed with AI support shows promise against pancreatic cancer in preclinical studies

JACKSONVILLE, Fla. — Mayo Clinic researchers have developed an experimental drug with the help of artificial intelligence (AI) to target the "undruggable" PDZ-domain of GIPC1 protein that helps different types of cancer, including pancreatic cancer, to grow and resist treatment. In laboratory studies, the drug slowed tumor growth, improved survival and enhanced the effects of […]

Research News

Researchers discover immune ‘off switch’ used by cancer cells

ROCHESTER, Minn. — Mayo Clinic researchers have identified a protein that cancer cells use to shut down the body's immune response, a discovery that could help scientists develop new treatments that make cancer immunotherapies more effective. Published in the Journal of Clinical Investigation, the study identifies a previously unknown role for a protein called TRAILshort, […]

Research News

Mayo Clinic study highlights benefits of animal-assisted treatment in stroke rehabilitation (VIDEO)

ROCHESTER, Minn. — A visit from a therapy animal may do more than lift spirits. A new study in Mayo Clinic Proceedings highlights how animal-assisted treatment can support inpatient stroke rehabilitation. Patients who interacted with therapy animals showed greater engagement in their treatment, increased physical activity and longer mobility compared with those who did not. […]

Research News

Mayo Clinic Platform and Einstein Hospital Israelita advance global AI health innovation with secure data collaboration

SAO PAULO and ROCHESTER, Minn. — Mayo Clinic and Einstein Hospital Israelita today announced a milestone in their collaboration to advance responsible artificial intelligence (AI)-enabled healthcare innovation. Einstein's de-identified clinical data is now available through Mayo Clinic Platform's secure, privacy-preserving global healthcare innovation ecosystem. The collaboration strengthens South American representation in global health datasets and […]

Research News

When it’s not MS: Inside the discovery of MOGAD

For years, some patients diagnosed with multiple sclerosis (MS) weren't getting better despite receiving the right treatments. The problem wasn't the therapy. It was the diagnosis. A new episode of "Tomorrow's Cure" podcast explores how the discovery of myelin oligodendrocyte glycoprotein antibody-associated disease, or MOGAD, transformed the understanding of autoimmune neurologic disease. Once mistaken for […]

Research News

Mayo Clinic research advances understanding of senescent ‘zombie’ cells, healthy aging

ROCHESTER, Minn. — A series of Mayo Clinic studies is helping reshape scientists' understanding of senescent, or "zombie," cells — aging cells that no longer divide but remain metabolically active and release inflammatory molecules that contribute to age-related diseases. Published across Nature journals, the studies authored by scientists within the Robert and Arlene Kogod Center […]

Research News

Scientists identify new mitochondrial pathway linked to harmful inflammation in aging

ROCHESTER, Minn. — Researchers have uncovered a previously unknown mechanism that helps aging cells drive the chronic inflammation linked to many age-related diseases. The findings reveal how dysfunctional mitochondria — the cell's energy-producing structures — work with the cell's epigenetic machinery to switch on inflammatory genes, opening the door to a new therapeutic approach for […]