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in Dr. Chini's lab, Karina Kanamori Mendes, M.D., measures mitochondrial activity in a muscle sample from a clinical trial subject

Science Saturday: From fasting to a pill? Mayo Clinic scientists explore the biology of caloric restriction

New year, same topics: nutrition, healthy eating and slowing the downhill roll of aging. Eat this, not that — never that — and try this one weird thing to look younger, right? Advice spans the spectrum from dubious to scientifically supported, but there is an approach that sidesteps it all: eat less. Either in a specific time frame or in general, limiting calories safely is called caloric restriction, food restriction or fasting. It's not a…

Mayo Clinic discovery in bone marrow cancer points to potential drug targets

ROCHESTER, Minn. — New research from Mayo Clinic's Center for Individualized Medicine finds that patients with ASXL1-mutant chronic myelomonocytic leukemia — an uncommon type of cancer of the bone marrow — have distinctive epigenetic changes that can activate harmful genes and cause the cancer to grow faster. The ASXL1 genetic mutation also can transform the disease into the more aggressive acute myeloid leukemia. The study, published in Nature Communications, helps to clarify a potential therapeutic…

Senior couple sit together on a couch in their living room

Plasma biomarker screening could improve accuracy, health equity in Alzheimer's disease diagnosis

JACKSONVILLE, Fla. — Mayo Clinic researchers have identified a new set of molecular markers in blood plasma. This discovery could lead to the development of improved diagnostic tests for Alzheimer's disease. Alzheimer's disease is the most common form of dementia, affecting 6.2 million people in the U.S. The Mayo Clinic study, published in eBioMedicine, is the first study to focus on RNA molecules in plasma as biomarkers for Alzheimer's disease in African Americans — the…

Scientist examining DNA results on a screen during an experiment in the laboratory

Mayo Clinic study reports genomic data disparities among racial groups

ROCHESTER, Minn. ― Mayo Clinic researchers studied the differences in genomic data quality among racial groups in one of the largest and most widely used cancer research datasets, The Cancer Genome Atlas. "We found lower quality genomic sequencing data in self-reported Black patients and patients of African ancestry," says Yan Asmann., Ph.D., a Mayo Clinic bioinformatician and senior author of the study. "This finding serves as a reminder that when designing, conducting and interpreting cancer…