DNA double-strand breaks (DSBs) are posing serious threats to genome stability. During mitosis, cells mainly rely on polymerase theta (Polθ) -mediated repair to fix these breaks. However, how the CIP2A-TOPBP1 complex regulates this process remains unclear. In a study published in PNAS , a team led by Prof. ZHAO Guoping from the Hefei Institutes of Physical Science of the Chinese Academy of Science
Medical ResearchLife SciencesProteins#Chinese Academy of Sciences#Research News#Proteins#medical research#clinical research#genomics#biology
Have you ever wondered how a flower ensures that it's pollen-catching "landing pad" (the stigma) stays neatly separated from the "pollen tube highway" beneath it (the style)? This clear boundary is crucial for plant reproduction, but for decades, biologists didn't know how it was drawn. In a study published in PNAS , researcher s from the Institute of Botany of the Chinese Academy of Sciences (CAS
Life SciencesEvolution#Chinese Academy of Sciences#Research News#Evolution#genomics#biology
Scientists have recently reconstructed the ancestral karyotype of the banana family, revealing how chromosome numbers decreased stepwise from 17 to 9 - 11 over evolutionary time. The study was led by scientists from the South China Botanical Garden (SCBG) of the Chinese Academy of Sciences (CAS), in collaboration with researchers from Sichuan University and other institutions . The findings were p
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In a study published in Science , a team led by Prof. ZHOU Bin from the Center for Excellence in Molecular Cell Science (Shanghai Institute of Biochemistry and Cell Biology) of the Chinese Academy of Sciences, along with Prof. LIU Kathy O. from The Chinese University of Hong Kong, developed a series of genetic lineage-tracing tools to investigate the origins of newly formed coronary collateral art
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In a study published in Cell , a team led by Prof. ZHOU Bin from the Center for Excellence in Molecular Cell Science (Shanghai Institute of Biochemistry and Cell Biology) of the Chinese Academy of Sciences, along with Prof. Ralf H. Adams from the Max Planck Institute for Molecular Biomedicine, Germany, reported the absence of lymphatic vessels in homeostasis and regenerating bone and their abnorma
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Adelaide researchers are challenging decades-old assumptions about brain cancer treatment in a bid to make radiation therapy more effective against tumours, while reducing damage to healthy tissue.
Using a new combination of computational tools to analyze ancient DNA , Yale researchers have discovered two ancient, extinct giant tortoise lineages that once lived on the Galapagos Islands.
The U.S. National Science Foundation is investing $90 million over five years to support three new NSF Science and Technology Centers (NSF STC). These centers will advance American leadership in…
Fusion EnergyMedical ResearchLife Sciences#U.S. National Science Foundation#fusion#plasma physics#medical research#clinical research#genomics#biology
Pertussis, or whooping cough, continues to cause periodic outbreaks worldwide and can be especially dangerous for infants who have not completed vaccination. Yet conventional surveillance depends on people seeking medical care, being tested, diagnosed, and reported, which can delay recognition of changes in community transmission.
Life Sciences#Osaka University#research#genomics#biology
Understanding and wielding the quantum properties of nature is the ambitious objective of eight research institutes that will collectively receive more than $290 million from the U.S. National Science…
Life SciencesTechnology & Innovation#U.S. National Science Foundation#genomics#biology#advanced materials#innovation
Stem cells possess the unique ability to self-renew and transform into different types of cells. For example, rare hematopoietic stem cells found in bone marrow can become any type of blood cell. Throughout life, they can produce new blood cells to replace those lost because of infection, bleeding, or chemotherapy. However, as people and animals age, hematopoietic stem cells become less effective.
Medical ResearchLife Sciences#Tohoku University#Research Releases#medical research#clinical research#genomics#biology
When Raghav Sehgal arrived at Yale as a graduate student several years ago, he wanted to explore the use of powerful computer science tools in cancer research. With an engineering background and a computational biology startup already under his belt, he was well prepared.
The first wave of blockbuster obesity medications, including semaglutide (Ozempic, Wegovy) and tirzepatide (Zepbound, Mounjaro), transformed weight loss by achieving levels once thought possible only with bariatric surgery.
Two disorders with big names—trichotillomania (repeated hair-pulling) and excoriation disorder (repeated skin-picking)—were the focus of a recent Yale study looking at potential genetic causes. The two disorders are part of a group called body-focused repetitive behaviors, or BFRBs.
Australian researchers have uncovered a promising new way to tackle one of the most aggressive forms of breast cancer, raising hopes for more effective treatments to stop the disease from spreading.
