A University of Minnesota-led multi-institutional research team has discovered a highly potent small molecule that blocks Ebola virus entry by stabilizing the virus's entry protein and provides strong protection when given orally in a preclinical model.
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The human body is a marvel of remake and renewal. We regularly replace some of our estimated 37 trillion cells – about 300 billion or 1 percent of our cells each day - with healthy substitutes. We remove damaged or aging, senescent cells and cellular debris from our organs and tissues every second of the day. How important is it that cellular waste be properly removed?
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Researchers at the Swammerdam Institute for Life Sciences (SILS) of the Faculty of Science have uncovered how mammary-gland cells decide when to activate Wnt4, a gene with a central role in mammary-gland development. Their findings reveal how distant stretches of non-coding DNA work together in three dimensions to control gene activity.
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Scientists recently discovered various Denisovan remains in Southwest China dating back to the late Middle Pleistocene, including the first Denisovan radius—one of two long bones in the forearm. Denisovans are a genetically identified archaic hominin group believed to have been widely distributed across Asia. However, due to the limited number of fossil remains, especially postcranial bones—those
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The Lasker Foundation has announced that UT Southwestern sleep researcher Masashi Yanagisawa, M.D., Ph.D., is a recipient of the 2026 Albert Lasker Basic Medical Research Award for his discovery of orexin, a brain peptide that maintains wakefulness, and demonstration that the absence of its action is responsible for narcolepsy, a profound disorder of sleep.
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A recent study in Nature Energy has quantified how cell-to-cell inconsistency limits the performance, lifetime, and resource utilization of electric vehicle (EV) battery packs under real-world operating conditions. The work revealed that a small number of faster-ageing cells can severely constrain an entire pack's performance and lifespan. The study was led by Prof. CHEN Zhongwei from the Dalian I
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Triplet excited states of organic molecules play essential roles in photocatalysis, photodynamic therapy, photon upconversion, and organic optoelectronic applications. However, achieving efficient triplet generation in purely organic molecules remains challenging because of their intrinsically weak spin–orbit coupling. Spin–orbit charge-transfer intersystem crossing (SOCT-ISC) has emerged as a pro
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Understanding how domestication reshapes brain structure and function remains a fundamental question in evolutionary biology. The hippocampus is a key brain region involved in memory and stress regulation, and it has been thought to undergo "simplification" during domestication. However, the cellular mechanisms underlying these changes remain poorly understood. In a study published in PNAS on Sept
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Cilia and flagella are antenna‑like organelles that project from the cell surface and are widely distributed from unicellular eukaryotes to mammals. Motile cilia must beat in a coordinated manner to generate productive fluid flow and drive cell motility, which is essential for processes such as sperm propulsion, mucociliary clearance in the airways, and cerebrospinal fluid circulation. Now, a rese
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