Coagulation factor XIa (FXIa) is a key protease in the intrinsic coagulation pathway. It plays a central role in pathological thrombosis and has little impact on the normal hemostasis process. It is a safe target for the development of a new generation of anticoagulant drugs.
Liver fibrosis is a common pathological pathway in most chronic liver diseases, and its essence is the excessive deposition of extracellular matrix in the liver. Macrophages play a central regulatory role in the occurrence and regression of liver fibrosis, but their functional selection mechanism between promoting scar formation and driving scar regression has long been unresolved.
Water isotope separation and identification are key technologies in the fields of medicine, chemistry and life sciences. The molecular size and macroscopic physical and chemical properties of water (H 2 O) and heavy water (D 2 O) are highly similar, and their equilibrium adsorption differences in porous media are limited. It is difficult to determine the cause of isotope differences based on the final adsorption amount alone. Therefore, constructing a thin film with oriented narrow channels, moderate frame flexibility, and proton-electron coupling conduction, and collaboratively analyzing the multi-stage transmission process through mass and electrical signals is the key to realizing real-time identification of the confinement behavior of water isotopes.
Research#Chinese Academy of Sciences#科研进展#CAS#Lawrence Berkeley National Laboratory
As cyber threats become increasingly sophisticated and digital technology plays a larger role in Australia’s defence, developing people with the skills to protect critical systems is becoming a national priority.
Dogs trained in scent detection may be better at sniffing out the right smell after breakfast, with new research finding hungry dogs that are working for treats are more likely to falsely identify the wrong scent.
ResearchMedical Research#Adelaide University#Adelaide#medical research#clinical research
This summer, Birch Aquarium at Scripps Institution of Oceanography at UC San Diego released 223 Mountain Yellow-legged Frogs into their native habitat in Southern California’s San Jacinto Mountains.
Research#University of California San Diego#UC San Diego#UCSD Today
Thirteen percent of U.S. children aged 3–17 have a diagnosed mental or behavioral health condition, and American youth suicide rates far exceed those of peer countries. But the popular story — a sudden, smartphone-driven collapse — doesn't fit five decades of data. This series examines where the crisis comes from, which interventions demonstrably help, and what we still need to learn.
ResearchMedical Research#Yale University#research#Yale#Yale News#medical research#clinical research
Visual artists can consult a digital color wheel to test relationships between different shades. Audio engineers can alter soundwave frequencies to create complex tones and harmonies. But no digital tools exist that can predict how people will perceive the blend of scents wafting from a steaming cup of coffee or a freshly baked apple pie.
A University of Minnesota-led multi-institutional research team has discovered a highly potent small molecule that blocks Ebola virus entry by stabilizing the virus's entry protein and provides strong protection when given orally in a preclinical model.
Medical ResearchLife SciencesResearch#University of Minnesota Medical School#UMN Medical School#research#medical research#clinical research#genomics#biology
Des scientifiques de l'UdeM révèlent comment un bras de fer entre tissus à croissance rapide et à croissance lente sculpte le fruit chez une plante à fleurs.
President and Vice-Chancelor Marie-Eve Sylvestre is among five University of Ottawa researchers elected as fellows of the Royal Society of Canada (RSC) or members of its College of New Scholars, Artists and Scientists, one of Canada’s highest academic honours.
PET can observe human metabolism and molecular activities and plays an important role in tumor diagnosis and efficacy evaluation. Recently, the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences and others have made progress in the field of low-count PET imaging.
