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a tank of zebrafish in a research lab

Science Saturday: Time tempers anthracyclines into a toxin or treatment for cancer

For the millions of people who could face a cancer diagnosis this year, it's vital to have all therapeutic options available. But in some cases, the drugs used to treat cancer can cause other health problems during treatment or later. One example is a class of drugs called anthracyclines, which are derived from bacteria found in Italian soil decades ago. This group of about six chemotherapy drugs has been used since the 1960s to treat leukemia, lymphoma,…

Mayo Clinic researchers load CAR-T cells with oncolytic virus to treat solid cancer tumors

ROCHESTER, Minn. — Researchers at Mayo Clinic's Center for Individualized Medicine have devised an immunotherapy technique that combines chimeric antigen receptor-T cell therapy, or CAR-T cell therapy, with a cancer-killing virus to more effectively target and treat solid cancer tumors.  The combination approach, published in Science Translational Medicine, involves loading CAR-T cells, which are engineered to look for antigens on cancer cells, with an oncolytic virus. Oncolytic viruses are naturally occurring viruses that can infect…